HPLC Method for the Analysis of Paracetamol, Caffeine and Dipyrone
نویسندگان
چکیده
Paracetamol (acetaminophen) is one of the most popular over-the-counter analgesic and antipyretic drugs. Paracetamol is available in different dosage forms: tablet, capsules, drops, elixirs, suspensions and suppositories. Dosage forms of paracetamol and its combinations with other drugs have been listed in various pharmacopoeias. The combination of paracetamol with dipyrone is used as an antipyretic, analgesic and antiinflammatory drug. Numerous methods have been reported for the analysis of paracetamol and its combinations in pharmaceuticals or in biological fluids. Paracetamol has been determined in combination with other drugs using titrimetry, voltammetry, fluorimetry, colorimetry, UV-spectrophotometry7−9, quantitative thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC)11−16 and gas chromatography (GC) in pharmaceutical preparations. Dipyrone is an analgesic, antipyretic, and antiinflammatory drug. After oral administration it is hydrolyzed to 4-methylaminoantipyrine and further metabolized to 4-aminoantipyrine, 4-formylaminoantipyrine, and 4-acetylaminoantipyrine. Dipyrone (noramidopyrine methanesulfonate sodium, metamizole) is a water-soluble pyrazolone derivative drug available in oral and parenteral forms. For more than 60 years it has been used as an analgesic,
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